People are afraid to do things to motors that they have no experience with. You can turbo a high compression motor just as easily as a low compression setup.
The benefits to the high compression is that you will still have the torque generated from higher compression on the low side and it will require less boost to generate more power. Is there a trade off, yes of course there is. Heat!!!! High compression and pressurized air create a lot of heat so proper tuning is an absolute must.
I am preparing a new build setup soon on a high compression LS/VTEC turbo build and I will let you know how it turns out, 1 word. Beast.
I would at least settle for some kind of engine management that is comparable to the Hondata S200. Personally I have the Hondata S300 for my application because tuning on the fly and live data is a must for me. However Chrome, Uberdata, ect will work just fine you just have to remove the ROM everytime you want to make changes and reburn it. So you will require the Moates Burn2
http://support.moates.net/2008/08/30/burn2/